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The Effect of Vagus Nerve Stimulation on the Inflammatory Response After Lung Lobectomy

O

Otto Wagner Hospital

Status

Completed

Conditions

Inflammatory Response

Treatments

Device: Vagus nerve stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT03204968
Vagus Stimulation

Details and patient eligibility

About

Systemic inflammation is a potentially debilitating complication of thoracic surgeries that can result in significant physical and economic morbidity for afflicted patients. There is compelling evidence for the role of central nervous system in the regulation of systemic inflammatory responses through humoral mechanisms. Activation of afferent vagus nerve fibers by cytokines triggers anti-inflammatory responses. Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxemia in rats inhibited Tumor necrosis factor (TNF) synthesis in liver preventing the development of shock. The vagal regulatory role of systemic inflammation after lung lobectomy is unknown.

Enrollment

130 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Lung Lobectomy or pneumonectomy
  • Adult
  • Open surgery

Exclusion criteria

  • Current infection

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

130 participants in 2 patient groups

control
No Intervention group
Treated
Active Comparator group
Treatment:
Device: Vagus nerve stimulation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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