The Effect of Vagus Nerve Stimulation on the Inflammatory Response After Lung Lobectomy

Otto Wagner Hospital

Status: Completed

Conditions: Inflammatory Response

Treatments: Device: Vagus nerve stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03204968

Vagus Stimulation

Details and patient eligibility

About

Systemic inflammation is a potentially debilitating complication of thoracic surgeries that can result in significant physical and economic morbidity for afflicted patients. There is compelling evidence for the role of central nervous system in the regulation of systemic inflammatory responses through humoral mechanisms. Activation of afferent vagus nerve fibers by cytokines triggers anti-inflammatory responses. Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxemia in rats inhibited Tumor necrosis factor (TNF) synthesis in liver preventing the development of shock. The vagal regulatory role of systemic inflammation after lung lobectomy is unknown.

Enrollment: 130 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Lung Lobectomy or pneumonectomy
• Adult
• Open surgery

Exclusion criteria

• Current infection

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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130 participants in 2 patient groups

control

No Intervention group

Treated

Active Comparator group

Treatment:

Device: Vagus nerve stimulation