The Effect of Various External Pressure on Blood (EPB)

Hyub Huh

Status: Completed

Conditions: Hemorrhage

Treatments: Device: Auto PC(Acemedical, Goyang-si, Korea) - 200mmHg; Device: Auto PC(Acemedical, Goyang-si, Korea) - 250mmHg; Device: Auto PC(Acemedical, Goyang-si, Korea) - 150mmHg; Device: Auto PC(Acemedical, Goyang-si, Korea) - 300mmHg; Device: Auto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control)

Study type: Interventional

Funder types: Other

Identifiers

NCT02520999

BP300

Details and patient eligibility

About

Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used. The investigators will study correlation between external pressure and hemolysis and deformability of red blood cell.

Full description

Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used which cause hemolysis and alteration of red blood cell. The investigators will study correlation between variable external pressure and hemolysis and deformability of red blood cell. Differ from previous study, the investigator will use scanning electron microscope for observation red blood cell.

Enrollment: 25 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers, without any underlying disease.

Exclusion criteria

• history of delivery, abortion in past 6 months.
• weight : male under 50kg, female under 45kg
• heart rate under 50 or over 100
• fever : over 37.5
• blood pressure : over 180/100

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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25 participants in 2 patient groups

5days

Active Comparator group

Description:

5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.

Treatment:

Device: Auto PC(Acemedical, Goyang-si, Korea) - 250mmHg

Device: Auto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control)

Device: Auto PC(Acemedical, Goyang-si, Korea) - 150mmHg

Device: Auto PC(Acemedical, Goyang-si, Korea) - 300mmHg

Device: Auto PC(Acemedical, Goyang-si, Korea) - 200mmHg

35days

Active Comparator group

Description:

35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.

Treatment:

Device: Auto PC(Acemedical, Goyang-si, Korea) - 250mmHg

Device: Auto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control)

Device: Auto PC(Acemedical, Goyang-si, Korea) - 150mmHg

Device: Auto PC(Acemedical, Goyang-si, Korea) - 300mmHg

Device: Auto PC(Acemedical, Goyang-si, Korea) - 200mmHg