The Effect of Vasopressors on Cerebral Oxygentaion During Off Pump CABG

Seoul National University

Status: Completed

Conditions: Cerebral Oxygen Saturation

Treatments: Drug: Norepinephrine; Drug: Phenylephrine; Drug: Vasopressin

Study type: Interventional

Funder types: Other

Identifiers

NCT04214145

OPCAB_vasopressor

Details and patient eligibility

About

The purpose of this study is to analyze the changes in cerebral oxygen saturation during the use of three vasopressors, phenylephrine, norepinephrine, and vasopressin, which are currently used during coronary artery bypass grafting.

Enrollment: 90 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing off pump coronary artery bypass.

Exclusion criteria

• Patient refusal
• Preoperative vasopressor use
• Preoperative mechanical circulatory support
• Concurrent cerebrovascular or head and neck surgery
• Technical difficulty of measuring brain oxygen saturation
• Redo coronary artery bypass surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 3 patient groups

Phenylephrine

Experimental group

Treatment:

Drug: Phenylephrine

Norepinephrine

Experimental group

Treatment:

Drug: Norepinephrine

Vasopressin

Experimental group

Treatment:

Drug: Vasopressin