The Effect of Vinegar Consumption on Visceral Fat and Blood Glucose Concentration (VIVO)

Carol Johnston

Status: Completed

Conditions: Visceral Obesity; Insulin Resistance; Tooth Erosion

Treatments: Dietary Supplement: vinegar pill; Dietary Supplement: liquid vinegar

Study type: Interventional

Funder types: Other

Identifiers

NCT03577834

vinegar_visceral_fat

Details and patient eligibility

About

The purpose of this study is to test the potential ability of vinegar to significantly decrease visceral fat in healthy adults with "central obesity". During the 8-week trial, participants will either consume a low-dose vinegar pill (control treatment) or a vinegar drink twice per day.

Research Aim and Hypothesis H1 Daily vinegar consumption will be associated with loss in visceral fat (as measured by DXA) after 8 weeks compared to the placebo treatment (low-vinegar pill) in a group of healthy adults with "central obesity".

H2 Daily vinegar consumption will be associated with a decrease in abdominal circumference after 8 weeks compared to the placebo treatment (low-vinegar pill) in a group of healthy adults with "central obesity".

Full description

This randomized, placebo-controlled experimental trial will last 8 weeks. At the initial visit (consenting visit lasting about 20 minutes) the participant will sign the consent and complete a short health questionnaire and a short questionnaire on tooth erosion. Body height and weight and waist circumference will also be measured. Qualifying participants will be stratified by gender, age, weight, and waist circumference, then randomized into two groups: the intervention group, vinegar drinks (VIN) or the control group, vinegar pills (CON). The participants will know which treatment they are given but they will not know which group (control vs. placebo) they are in. Those who receive the VIN will be instructed to drink 2 tablespoons of red wine vinegar (provided) mixed with water twice each day for weeks 1 to 8 of the trial. Those in the CON group will be instructed to take one vinegar pill (provided) each day for weeks 1-8 of the trial. Participants will be instructed to maintain their current diet and exercise habits during the study.

Enrollment: 102 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Nonsmoking
• Not pregnant or lactating if female
• No active disease state or medication use affecting blood glucose or cholesterol (additionally, individuals on digoxin or diuretics will be excluded but other medications in use >3 months will be allowed)
• No food restrictions or special diet
• BMI range: 22-35
• Waist circumference >34 (women) and >39 (males)
• Sedentary (exercising < 3 days/week)

Exclusion criteria

• Unwilling to take a vinegar supplement daily for 8 week or follow other aspects of study protocol
• Recent abdominal surgery or condition causing abdominal discomfort/distention (such as acid reflux, ascites, pancreatitis, diverticulitis/diverticulosis, Crohn's disease, and/or irritable bowel syndrome)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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102 participants in 2 patient groups, including a placebo group

Liquid vinegar

Experimental group

Description:

Participants in this arm were instructed to drink 2 tablespoons of red wine vinegar (provided) mixed with water twice each day for weeks 1 to 8 of the trial.

Treatment:

Dietary Supplement: liquid vinegar

Vinegar pill

Placebo Comparator group

Description:

Participants in the control group were instructed to take one vinegar pill (provided) each day for weeks 1-8 of the trial.

Treatment:

Dietary Supplement: vinegar pill