The Effect of Vinegar on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes

Attikon University Hospital

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Dietary Supplement: Vinegar; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02309424

167/11-06-08

Details and patient eligibility

About

This open, randomized, cross-over, placebo-controlled study aims to investigate the effects of vinegar on glucose metabolism, endothelial function and circulating lipid levels in subjects with impaired glucose tolerance or type 2 diabetes, using the arteriovenous difference technique.

Full description

Subjects with IGT or type 2 diabetes will be randomised to consume 20ml vinegar (6% acetic acid) or placebo before a mixed meal. Plasma samples will be taken for 300min from the radial artery and from a forearm vein for measurements of glucose, insulin, triglycerides, non-esterified fatty acids (NEFA) and glycerol. Muscle blood flow will be measured with strain-gauge plethysmography. Glucose flux will be calculated as the arteriovenous difference of glucose multiplied by the blood flow rates.

Enrollment: 20 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Subjects with impaired glucose tolerance or newly diagnosed type 2 diabetes before the initiation of medication therapy
2. Recreationally active
3. With stable body weight and diet during the last two months.

Exclusion criteria

1. Any systemic disease (besides glucose abnormalities)
2. Any medication therapy
3. Diabetic complications

Trial design

20 participants in 2 patient groups, including a placebo group

Vinegar

Active Comparator group

Description:

0,50mmol vinegar (6% acetic acid)

Treatment:

Dietary Supplement: Vinegar

Placebo

Placebo Comparator group

Description:

50 ml water

Treatment:

Other: Placebo