The Effect of Viral Load on Intrahepatic Recurrence in Hepatitis B Virus (HBV)-Related Hepatocellular Carcinoma (HCC)

Seoul National University

Status: Completed

Conditions: Carcinoma, Hepatocellular; Chronic Hepatitis B

Treatments: Procedure: PEIT; Procedure: RFTA

Study type: Interventional

Funder types: Other

Identifiers

NCT00397540

10-2006-001

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of serum hepatitis B virus (HBV) DNA level on intrahepatic recurrence in locally treatable hepatocellular carcinomas (HCCs) related with HBV.

Full description

Prospective cohort study

Survival

• Overall survival rate
• Disease free survival rate

Recurrence

• Cumulative recurrence rate

Enrollment: 145 patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Child-Pugh Class A or B
• Maximal tumor size less than 5 cm
• No previous history of treatment for hepatocellular carcinoma
• Recurrent hepatocellular carcinoma located more than 2 cm from the previous cancer site and is found more than 1 year's gap

Exclusion criteria

• Hepatocellular carcinoma in portal vein
• Hepatocellular carcinoma in hepatic vein

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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145 participants in 2 patient groups

percutaneous ethanol injection therapy

Active Comparator group

Description:

Patients with hepatocellular carcinoma who will be treated with PEIT (percutaneous ethanol injection therapy)

Treatment:

Procedure: PEIT

radiofrequency thermal ablation

Active Comparator group

Description:

Patients with hepatocellular carcinoma who will be treated with RFTA (radiofrequency thermal ablation)

Treatment:

Procedure: RFTA