The Effect of Vitamin B3 on Substrate Metabolism, Insulin Sensitivity, and Body Composition in Obese Men

Aarhus University Hospital

Status: Completed

Conditions: Obese

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Nicotinamide riboside (NIAGEN TM, ChromaDex, CA, USA )

Study type: Interventional

Funder types: Other

Identifiers

NCT02303483

44081

Details and patient eligibility

About

In animals, treatment with vitamin B3 improved insulin sensitivity and substrate metabolism. It is currently not know if vitamin B3 has the same positive effects in humans. In the current study the effect of a 3 month treatment with vitamin B3 on insulin sensitivity and substrate metabolism in obese men will be investigated.

Enrollment: 40 patients

Sex: Male

Ages: 40 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• written signed consent
• male
• BMI>30 kg/(m2)
• age: 40-70
• no medication
• non-smoker

Exclusion criteria

• endocrine disease
• other severe disease
• high daily activity level (>30 min / day)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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40 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

lime tablets

Treatment:

Dietary Supplement: Placebo

Nicotinamide riboside (NR, Vit B3)

Experimental group

Description:

NIAGEN (ChromaDex) 1 g x 2 orally per day

Treatment:

Dietary Supplement: Nicotinamide riboside (NIAGEN TM, ChromaDex, CA, USA )