The Effect of Vitamin D on Bone Accretion and Turn-Over in Young Girls
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About
Objectives To evaluate the effect of increased vitamin D intake on vitamin D status, bone mass and bone turnover in young girls aged 12-13.
More specifically the effects on the following parameters will be assessed:
- Vitamin D metabolites.
- Parathyroid hormone.
- Bone turnover.
- Bone mineral accretion.
- Serum calcium and phosphate.
- Renal handling of calcium and phosphate.
Full description
This work package will consist of a randomised double blind one-year vitamin D supplementation study. Primary effect parameter is change in bone mineral content and therefore study duration will be one year. A total of 225 subjects, 75 in each of the three groups: one control and two intervention groups, will be included Two dosages of supplementation will be used: 5 µg per day and 10 µg per day.
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Volunteers
Inclusion criteria
- Girls born in Denmark with Danish citizenship aged 10.0-11.0 years living in the municipals of Copenhagen and Frederiksberg
Exclusion criteria
- Any chronical disease with influence on bone mass or turnover
- Intake of drugs with influence on bone mass or turnover
- Intake of calcium or vitamin D other than the intervention
Trial design
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Interventional model
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Data sourced from clinicaltrials.gov
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