The Effect of Vitamin D on in Vitro Fertilization Outcome

Zhengzhou University

Status: Completed

Conditions: In Vitro Fertilization; Ongoing Pregnancy Rate; Vitamin D

Treatments: Procedure: Embryo transfer

Study type: Observational

Funder types: Other

Identifiers

NCT02361827

RMCZZU-Vitamin D

Details and patient eligibility

About

To date, several studies have been done to explore the relationship between Vitamin D level and IVF outcome; however, the results are controversial. Sample sizes in these studies mentioned above were relatively small. In addition, there are no prospective cohort studies in this field. Thus, here the investigators carry this prospective observational cohort study to demonstrate the relationship between vitamin D level and IVF outcome.

Full description

Vitamin D level is measured before the commence of IVF cycle. According to Vitamin D level, patients are divided into 3 groups: A, Deficient, <20 ng/mL; B, Insufficient, 20-29.9 ng/mL; C, Replete, >30 ng/mL.

Ongoing pregnancy rate are compared among these three groups after controlling age, number of embryos transferred, ect.

In addition, Vitamin D level is also meassured before embryo transfer in FET cycles with PGT treatment. The effect of Vitamin D on IVF outcome is detected in patients transferred with Euploid embryos.

Enrollment: 688 patients

Sex: Female

Ages: 21 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. age between 21-40 years old
2. basal FSH hormone level less than 10 mIU/mL
3. the first cycle of IVF treatment with standard long protocol
4. both ovarian present and normal uterus.

Exclusion criteria

1. Important data missing
2. Gametes donation cycles
3. Anyone that does not meet the inclusion criteria

Trial design

688 participants in 6 patient groups

A1, Vitamin D deficient

Description:

Vitamin D level before cycle \< 20 ng/mL.

Treatment:

Procedure: Embryo transfer

B1, Vitamin D insufficient

Description:

Vitamin D level before cycle 20-29.9 ng/mL

Treatment:

Procedure: Embryo transfer

C1, Vitamin D replete

Description:

Vitamin D level before cycle \> 30 ng/mL

Treatment:

Procedure: Embryo transfer

A2, Vitamin D deficient

Description:

Vitamin D level before ET \< 20 ng/mL (FET with Euploid embryos)

Treatment:

Procedure: Embryo transfer

B2, Vitamin D insufficient

Description:

Vitamin D level before ET 20-29.9 ng/mL (FET with Euploid embryos)

Treatment:

Procedure: Embryo transfer

C2, Vitamin D replete

Description:

Vitamin D level before ET \> 30 ng/mL (FET with Euploid embryos)

Treatment:

Procedure: Embryo transfer