the Effect of Vitamin D on the Serum Thioredoxin, TBP-2, Thioredoxin Reductase, Gene Expression of TBP-2 in Patients With Type II Diabetes

Tehran University of Medical Sciences

Status and phase: Unknown; Phase 4

Conditions: Type 2 Diabetes

Treatments: Dietary Supplement: placebo; Dietary Supplement: vitamin D

Study type: Interventional

Funder types: Other

Identifiers

NCT01876563

17112

Details and patient eligibility

About

The aim of this study is the comparision between the effects of vitamin D or placebo supplementation for 2 months in serum level of thioredoxin, TBP-2 and thioredoxin reductase activity in patients with type 2 diabetes

Enrollment: 30 estimated patients

Sex: All

Ages: 30 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

literate, willingness to participation, diabetic patients 30- 60 years old, body mass index in the range 18.5- 35, avoidance of dietary supplements, vitamins and herbal products at least 3 months before and throughout the intervention -

Exclusion criteria

people who have used vitamin D supplements in last 3 months, having chronic renal disease , GI disease, Hepatobilliary diseases, hematological disorders, hypo- or hyperthyroidism, treatment with orlistat or sibutramine for weight loss, pregnancy and lactation, treatment with insulin or Thiazolidinediones, Smokers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

diabetes, vitamin D

Active Comparator group

Description:

patients with type 2 diabetes who receive 4000 IU/day vitamin D

Treatment:

Dietary Supplement: vitamin D

placebo, diabetes

Placebo Comparator group

Description:

patients with type 2 diabetes who receive one tab placebo

Treatment:

Dietary Supplement: placebo