The Effect of Vitamin D Supplementation on Dental Implant Osseointegration: A Randomized Controlled Trial

Ziauddin University

Status: Completed

Conditions: Osseointegration Failure of Dental Implant

Treatments: Drug: Vitamin D3; Drug: Vitamin E 400

Study type: Interventional

Funder types: Other

Identifiers

NCT06274216

4381021ABOS

Details and patient eligibility

About

Dental implantation is a new technique for the single or more missing tooth replacement. Dental professionals might utilize the findings of this investigation to generate local data and learn more about how vitamin D affects bone metabolism and implant osseo-integration. The long-term success of dental implants would also be enhanced and preserved with the right medical use of vitamin D

Full description

Treatment option for replacing lost natural teeth is dental implants. Many factors are essential for the dental implant osse-ointegration, consisting of bone quality and volume, surgical approach and complications and host-associated factors like deficient nutritional status. By influencing bone metabolism, vitamin D, together with calcium, is essential for osseo-integrating implants. The significance of vitamin D supplementation in osseo-integration has received little attention in dental literature; there is little data involving people, and the majority of investigations have used animal models. Due to numerous environmental and dietary factors, international data is not applicable to our population. Latest study shows that 54% of the individuals were vitamin D deficient and 31% had vitamin D insufficiency in Pakistan.(Riaz et al., 2016) As well as Pakistani are less likely to expose to sun due to their full clothing, use of veil and Burqah. This research was therefore assessed the impact of vitamin D supplementation during dental implant osseointegration. In this research, the local data have been generated and dental implants in the presence of vitamin-D supplementation were tested for effectiveness.

Enrollment: 100 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients of age 18 to 45 years

• Patients of either gender
• Patients undergoing for dental implant
• Patients with Vitamin-D insufficiency

Exclusion criteria

Patients with any bone regenerative therapy prior to dental implants

• Patients with arthritis
• Patients with periodontal disease
• Patients with bleeding disorders
• Patients with poor oral hygiene
• Patients with uncontrolled hypertension and diabetes mellitus
• Patients with severe vitamin D deficiency
• Patients with chronic renal disease
• Patients on proton pump inhibitors
• Pregnant women

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

Group A

Experimental group

Description:

Patients in group A received 5000 IU of vitamin D3 orally every day for 12 weeks

Treatment:

Drug: Vitamin D3

Group B

Active Comparator group

Description:

Patients in group B received 400mg of vitamin E orally every day for 12 weeks

Treatment:

Drug: Vitamin E 400