The Effect of Vitamin D Supplementation on the Pulmonary Functions of Adult Asthmatic Egyptian Patients

Cairo University (CU)

Status and phase: Completed; Phase 4

Conditions: Asthma

Treatments: Dietary Supplement: Alfacalcidol

Study type: Interventional

Funder types: Other

Identifiers

NCT02747381

CL (1122)

Details and patient eligibility

About

This study evaluates the effect of vitamin D supplementation in the form of Alfacalcidol on the the pulmonary function of adult asthmatic Egyptian patients

Full description

Asthmatic patients are recruited and divided into two groups. One receives Alfacalcidol beside their normal medications while the other acts as a control group receiving the normal asthma medication.

Both groups are followed up for four months.

Enrollment: 82 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients diagnosed with asthma
2. Non-smokers

Exclusion criteria

1. Liver impairment
2. Kidney impairment
3. Patients receiving digoxin
4. Known hypersensitivity to 1α-hydroxyvitamin D3, vitamin D or any of its analogues and derivatives
5. Hypercalcaemia
6. Hyperphosphatemia
7. Pregnancy and breast-feeding
8. Patients on nutritional supplements with a potential effect on 25(OH)D serum concentrations
9. Had a History of stones in the urinary tract or diseases of calcium or bone metabolism

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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82 participants in 2 patient groups

intervention

Experimental group

Description:

receive Alfacalcidol 1 mcg daily for 4 months beside the conventional asthma medications

Treatment:

Dietary Supplement: Alfacalcidol

control

No Intervention group

Description:

Asthmatic patients receiving conventional asthma medications