The Effect of Vitamin K Supplementation on Glucose Metabolism

Seoul National University

Status and phase: Completed; Phase 4

Conditions: Prediabetic State; Diabetes

Treatments: Drug: Placebo; Drug: Menatetrenone

Study type: Interventional

Funder types: Other

Identifiers

NCT00960973

Vitamin K

Details and patient eligibility

About

The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response.

Full description

Recently, many studies have reported that vitamin K metabolism is related to glucose metabolism. The suggested mechanisms connecting vitamin K metabolism and glucose metabolism, are inflammation responses and osteocalcin effect on glucose metabolism. Most of the studies have investigated fasting glucose and insulin sensitive index, few have assessed glucose-intake-stimulated responses in regard to vitamin K supplementation. The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response using intravenous glucose tolerance test.

Enrollment: 42 patients

Sex: Male

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male volunteer older than 20 years

Exclusion criteria

• Subjects with (a history of) diabetes
• Subjects receiving medication related to diabetes or obesity
• Subjects receiving warfarin

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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42 participants in 2 patient groups, including a placebo group

Vitamin K

Experimental group

Description:

Vitamin K supplementation (menatetrenone 30 mg, 3 times a day for 4 weeks)

Treatment:

Drug: Menatetrenone

Placebo control

Placebo Comparator group

Description:

Placebo control

Treatment:

Drug: Placebo