The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery

Aretaieio Hospital

Status and phase: Unknown; Phase 4

Conditions: Liver Surgery; Apoptosis

Treatments: Procedure: Liver surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT01267786

AnesthSurg1

Details and patient eligibility

About

The aim of the study is to investigate the effect of sevoflurane and desflurane on hepatic function after ischemic/reperfusion injury and the sequence influence on renal and cardiovascular systems.

Enrollment: 40 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing liver surgery

Exclusion criteria

• ASA IV, Cardiovascular diseases

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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40 participants in 2 patient groups

Sevoflurane

Active Comparator group

Description:

1MAC intraoperatively

Treatment:

Procedure: Liver surgery

desflurane

Active Comparator group

Description:

1 MAC intraoperatively

Treatment:

Procedure: Liver surgery