The Effect of Warm Local Anesthetic Solution on Epidural Anesthesia

Hallym University Kangnam Sacred Heart Hospital

Status: Completed

Conditions: Cesarean Section

Treatments: Other: Temperature

Study type: Observational

Funder types: Other

Identifiers

NCT03860402

kangnamANE

Details and patient eligibility

About

The investigators are going to compare the onset and duration of nerve blockage with the use of pre-warmed (38°C) and room temperature (20°C) local anesthetic solutions (ropivacaine and fentanyl) on epidural anesthesia for cesarean section, and compare the incidence of complications such as hypotension, nausea and vomiting.

Full description

Spinal anesthesia has a shorter time to onset than epidural anesthesia, and the amount of local anesthetic administered is lower than that of epidural anesthesia, resulting in less systemic toxicity and superior block effect.

However, there are disadvantage that it is difficult to control the block height and the incidence of hypotension is high.

On the other hand, epidural anesthesia has the advantages of less sudden hypotension due to slow autonomic blockade, but it has a disadvantage that sensory nerve and motor nerve block time is delayed compared to spinal anesthesia.

The degree of nerve block for cesarean section surgery requires a high level of anesthesia above the T6 level, so the frequency of hypotension is high due to rapid sympathetic block after spinal anesthesia.

In this respect, hemodynamically stable epidural anesthesia is preferred when performing anesthesia for cesarean section.

The investigators are going to compare the onset and duration of nerve blockage with the use of pre-warmed (38°C) and room temperature (20°C) local anesthetic solutions (ropivacaine and fentanyl) on epidural anesthesia for cesarean section, and compare the incidence of complications such as hypotension, nausea and vomiting.

Enrollment: 50 patients

Sex: Female

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Among the pregnant women who were administered cesarean section in this study, those who agreed to participate in this study.

Exclusion criteria

• Fetal distress requiring fast delivery.
• Patients with hypersensitivity, allergic response, resistance to the drugs used in this study (fentanyl, ropivacaine, lidocaine).
• Patients who is not possible for regional anesthesia
• Patients who refused to participate in this study.
• Patients who cannot read or understand the agreement.
• Patients whose weight is less than 50kg or exceeds 100kg.

Trial design

50 participants in 2 patient groups

Pre-warmed drug

Description:

Pre-warmed (38°C) ropivacaine (7.5mg/ml) 19ml and fentanyl 50ug are injected via the epidural route at the L3-4 interspace.

Treatment:

Other: Temperature

Room temperature drug

Description:

Room temperature (20°C) ropivacaine (7.5mg/ml) 19ml and fentanyl 50ug are injected via the epidural route at the L3-4 interspace.