The Effect of Water Intake on Glucose Regulation (INDIGO-I)

Arizona State University (ASU)

Status: Withdrawn

Conditions: Glucose Metabolism Disorders; Water Deprivation; Dehydration (Physiology)

Treatments: Other: Water intake manipulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03765008

FP00018531

Details and patient eligibility

About

There is a growing body of evidence suggesting low water intake and elevated levels of the hormone vasopressin exacerbate glucose regulation. This project will examine the physiological mechanism by which low water intake impairs glucose homeostasis.

In the current proposal we aim to: 1) quantify the degree of glucose impairment as a response to elevated vasopressin due to low water intake and 2) identify the physiological mechanism by which elevated vasopressin, as a response to low water intake, impairs glucose regulation

Sex: All

Ages: 30 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

BMI 27.5-35

Exclusion criteria

• BMI <27.5 or >35
• high physical activity
• diabetes
• impaired liver or kidney function
• cardiovascular disease
• weight change of more than 3 kg in the past month
• pregnancy
• previous surgery on digestive tract (except appendectomy)
• fluid balance will be exclusionary such as
• serotonin re-uptake inhibitors.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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0 participants in 2 patient groups

High Water intake

Active Comparator group

Description:

5-days of High water intake according to IOM guidelines

Treatment:

Other: Water intake manipulation

Low Water Intake

Experimental group

Description:

5-days of Low water intake of 500 mL/day

Treatment:

Other: Water intake manipulation