The Effect of Weight Loss on Serum Mannose-Binding Lectin(MBL) Levels (WLMBL)

University of Aarhus

Status: Completed

Conditions: Weight Loss; Obesity

Treatments: Other: Weight loss

Study type: Interventional

Funder types: Other

Identifiers

NCT00854412

MBL1

Details and patient eligibility

About

High levels of mannose-binding lectin (MBL), an activator of a part of the immune system called the complement system, have been associated with increased mortality and risk of early signs of kidney damage in patients with type 2 diabetes. The effect of weight loss and changes in insulin resistance on MBL levels have been poorly elucidated.

This study includes 36 nondiabetic obese subjects, who will receive a very low- calorie diet (VLCD) of 800 kcal/day for 8 weeks.

Fasting blood samples will be obtained at baseline and after 8 weeks of VLCD and concentrations of MBL, glucose and insulin will be measured. Insulin resistance is assessed using the HOMA-IR method.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Obese

Exclusion criteria

• Diabetes
• Other severe disease

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)