The Effect of Zinc on Iron Bioavailability From Fortified Extruded Rice Fortified With Ferric Pyrophosphate (Rice_FeZn)

Federal Institute of Technology (ETH) Zurich

Status: Completed

Conditions: Iron Deficiency

Treatments: Other: Ferric Pyrophosphate; Other: Ferric Pyrophosphate and Zinc Oxide; Other: Ferric Pyrophosphate and Zinc Sulfate; Other: Ferrous sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT02255942

Rice-FePP-Zn

Details and patient eligibility

About

Investigation of Iron Bioavailability from extruded rice grains fortified with Ferric Pyrophosphate alone or in combination with different Zinc Compounds; Ferrous Sulfate serves as a Reference.

Full description

Ferric Pyrophosphate (FePP) is a water-insoluble, food grade, iron compound widely used to fortify rice and other foods as it causes no organoleptic changes to the food vehicles. However, it is only of low absorption in man and its absorption can be influenced by a variety of compounds. The effect of co-fortification of rice with ZnO respectively ZnSO4 on iron bioavailability in extruded rice fortified with FePP has never been investigated.

Enrollment: 20 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female
• Serum Ferritin Level < 15 µg/L
• Body weight <65 kg
• Signed informed consent 4. Body Mass Index in the range of 18.5 to 25

Exclusion criteria

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Iron fortified rice

Experimental group

Description:

Administration of iron fortified rice to all subjects; subjects will act as their own controls and each subject will receive all foreseen treatments/interventions.

Treatment:

Other: Ferric Pyrophosphate and Zinc Sulfate

Other: Ferric Pyrophosphate and Zinc Oxide

Other: Ferric Pyrophosphate

Other: Ferrous sulfate