The Effect of Zinc on the Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients

Cairo University (CU)

Status: Unknown

Conditions: Chronic Periodontitis

Treatments: Drug: Zinc Sulfate; Procedure: scaling and root planing

Study type: Interventional

Funder types: Other

Identifiers

NCT03923829

6653486

Details and patient eligibility

About

To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal therapy.

Full description

Hypozincaemia and hyperzincuria is known to be present in patients with type-2 diabetes, and Zinc supplementation is known to be helpful in restoring plasma Zinc levels to normal,Zinc's deficiency can lead to an increase in circulating glucose due to beta cells malfunctioning and resistance to insulin, which makes it easier for type 2 diabetes mellitus (DM2) to happen ,Zinc was found to be a structural part of key anti-oxidant enzymes such as superoxide dismutase (SOD), and Zinc deficiency impaired their synthesis, leading to increased oxidative stress

Enrollment: 34 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Controlled Type-2 diabetes mellitus
• Stage-II &III periodontitis
• At least 2 sites with clinical attachment loss 3 or 4 mm to ≥5 mm and radiographic bone loss 15% Extending to mid-third of root and beyond.
• Probing depth from ≤5 mm to ≥6 mm

Exclusion criteria

• Any periodontal or Antibiotic treatment during the last six months.
• Receiving trace element supplements in the previous three months
• Pregnant or lactating females
• Gastric or diuretic treatment
• Acute renal failure
• smoking

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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34 participants in 2 patient groups

Zinc administration with scaling and root planing

Experimental group

Description:

systemic administration of Zinc cap of 50 mg elemental zinc as zinc sulphate, once a day for 12 weeks in addition to scaling and root planing

Treatment:

Drug: Zinc Sulfate

scaling and root planing

Active Comparator group

Description:

scaling and root planing

Treatment:

Procedure: scaling and root planing