The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation Under Propofol-remifentanil Anesthesia in Elderly Patients

Yonsei University

Status: Completed

Conditions: General Surgery With Endotracheal Intubation

Treatments: Drug: remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT01720498

4-2012-0581

Details and patient eligibility

About

To find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients

Full description

The increase of Corrected QT (QTc) interval is associated with age. It is known that most inhalation anesthetics or intravenous anesthetics can influence the QTc. In addition, tracheal intubation during induction can stimulates sympathetic activity, which, as a results, prolong the QTc interval. Therefore, the aim of study is to find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients.

Enrollment: 50 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥ 65 years ASA class I-II who received surgery with endotracheal intubation

Exclusion criteria

• emergency surgery
• electrocardiography abnormality
• hypertension
• diabetes mellitus
• end stage renal disease
• moderate to severe cardiac disease
• moderate to severe liver dysfunction

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

50 participants in 2 patient groups

Male

Experimental group

Description:

To find out the effect site concentration of remifentanil for preventing QTc prolongation \< 15 sec during intubation : Dixon's up-and-down method

Treatment:

Drug: remifentanil

Female

Experimental group

Description:

To find out the effect site concentration of remifentanil for preventing QTc prolongation \< 15 sec during intubation : Dixon's up-and-down method

Treatment:

Drug: remifentanil