The Effectiveness and Outcomes of Epidural Analgesia in Patients Undergoing Open Hepatectomy

Chiang Mai University

Status: Completed

Conditions: Epidural Analgesia; Patient Controlled Analgesia

Treatments: Procedure: Open liver resection

Study type: Observational

Funder types: Other

Identifiers

NCT06301932

ANE-2562-06771

Details and patient eligibility

About

This observational study is to compare the effectiveness and outcomes of epidural analgesia in patients undergoing open hepatectomy: A propensity score matching analysis.

The main question is: What is the superior method of pain control in open hepatectomy: epidural analgesia or intravenous PCA?

Full description

After approval of the study protocol from the institutional review board of Chiangmai University (Approval number: ANE-2562-06771), the investigators performed a retrospective review of all patients who underwent an elective open liver resection in the specialized hepato-biliary center from January 2007 through December 2018. This retrospective inquiry comprised 612 patients. The data was systematically retrieved from electronic medical records. Baseline characteristics including age, gender, body mass index (BMI), co-morbidity, American Society of Anesthesiologists (ASA) classification, diagnosis, hepatitis profile, Child-Pugh classification, cirrhosis, the largest tumor size, previous liver resection, and pre-operative laboratory investigations were collected. The following intra-operative data were collected: type of liver resection, hilar resection, vascular reconstruction, intra-operative opioid consumption and type of fluid administration, estimated blood loss, packed red cell and blood product transfusion, and operation time. Post-operative pain score and opioid consumption also be collected.

Enrollment: 654 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All gender age above 18 years old
• Undergoing open liver resection surgery

Exclusion criteria

• No documentation of the numerical rating scale (NRS)
• Epidural failure

Trial design

654 participants in 2 patient groups

Epidural analgesia

Description:

Group of the patients received epidural analgesia

Treatment:

Procedure: Open liver resection

Non epidural analgesia

Description:

Group of the patients who did not received epidural analgesia

Treatment:

Procedure: Open liver resection