The Effectiveness of a Diet With Beef as Key Protein Component Versus a Plant-Based Diet to Support Integrated Muscle Protein Synthesis Rates in Healthy Older Individuals (OmniVeg_Diet)

Maastricht University Medical Centre (MUMC)

Status: Enrolling

Conditions: Muscle Protein Synthetic Response to Protein

Treatments: Other: Meat diet; Other: Plant diet

Study type: Interventional

Funder types: Other

Identifiers

NCT07049224

METC 24-025

NL87069.068.24 (Other Identifier)

Details and patient eligibility

About

Muscles are composed out of proteins. These proteins in turn are composed out of smaller building blocks, called amino acids. By consuming a sufficient amount of dietary protein, a sufficient amount of amino acids become available to build new muscle proteins. The body's ability to build these new muscle proteins is of great importance to maintain muscle strength and function.

Previous research suggests that a meal containing proteins from meat results in a better stimulation of the body's ability to build muscle proteins, when compared to a meal containing only plant-based proteins. However, these previous studies have only been performed following the ingestion of a single meal. As a result it is currently unknown how the muscles respond to a more prolonged ingestion of a diet containing animal/meat products, in comparison to a plant-based diet. Therefore, this study aims to investigate how fast new muscle proteins are being build when consuming a diet containing animal/meat products, in comparison to a plant-based (vegan) diet.

Enrollment: 32 estimated patients

Sex: All

Ages: 65 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male or female sex
• Aged between 65 and 85 y inclusive
• BMI between 18.5 and 30 kg/m2 inclusive

Exclusion criteria

• Not willing to consume meat/animal-based products during the study period
• Any food allergies (e.g. milk, gluten, etc.)
• Participating currently or in the 3 months prior to the study in a structured progressive exercise program.
• Smoking
• History of cardiovascular, respiratory, gastrointestinal, urogenital, neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine, haematological, immunologic disorders, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol, interfere with the execution of the experiment, or potential influence the study outcomes (to be decided by the study team and responsible physician)
• Diagnosed with phenylketonuria (PKU)
• Donated full blood 3 months prior to test day
• Use of any medications that interferes with study participation and/or outcomes (i.e. corticosteroids, non-steroidal anti-inflammatories, gastric acid suppressing medication) as assessed by the study team and responsible medical doctor.
• Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants
• Fasting blood glucose >7 mmol/L

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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32 participants in 2 patient groups

MEAT-PLANT

Experimental group

Description:

Participants will be subjected to a 10-day diet containing meat and animal products, followed by a 10-day diet containing plant products. During the interventional period participants will perform unilateral lower limb resistance exercise.

Treatment:

Other: Plant diet

Other: Meat diet

PLANT-MEAT

Experimental group

Description:

Participants will be subjected to a 10-day diet containing plant products, followed by a 10-day diet containing meat and animal products. During the interventional period participants will perform unilateral lower limb resistance exercise.

Treatment:

Other: Plant diet

Other: Meat diet