The Effectiveness of AAD and IPV to Treat Hospitalized Infants (<2years) With Acute Viral Bronchiolitis.

Vrije Universiteit Brussel

Status: Completed

Conditions: Bronchiolitis

Treatments: Other: inhalation 4ml hypertonic saline 3% 3x/day; Device: Intrapulmonary Percussive Ventilation; Procedure: Assisted Autogenic Drainage

Study type: Interventional

Funder types: Other

Identifiers

NCT02126748

FVG003

Details and patient eligibility

About

The purpose of this study is to investigate the effectiveness of two airway clearance techniques; Intrapulmonary Percussive Ventilation and Assisted Autogenic Drainage in hospitalized infants under the age of 2 with acute viral bronchiolitis.

Enrollment: 103 patients

Sex: All

Ages: 1 day to 24 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• first period of wheezing
• Wang score between 3 and 7
• age < 24 months
• Sa02> 90%

Exclusion criteria

• ICU patients
• mechanical ventilation
• use of antibiotics
• use of corticosteroids
• gestational age < 34 weeks
• chronic cardiac or pulmonary disease
• no parental consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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103 participants in 3 patient groups

Intrapulmonary Percussive Ventilation

Experimental group

Description:

20 min of IPV administered to the patient inhalation 4ml hypertonic saline 3% 3x/day

Treatment:

Other: inhalation 4ml hypertonic saline 3% 3x/day

Device: Intrapulmonary Percussive Ventilation

Assisted Autogenic Drainage

Active Comparator group

Description:

20 min of AAD administered to the patient inhalation 4ml hypertonic saline 3% 3x/day

Treatment:

Procedure: Assisted Autogenic Drainage

Other: inhalation 4ml hypertonic saline 3% 3x/day

control

No Intervention group

Description:

20 min of bouncing administered tot the patient inhalation 4ml hypertonic saline 3% 3x/day