The Effectiveness of Advanced Decision Support Tool (OPT-IVF) for IVF Treatment

National University of Malaysia

Status: Not yet enrolling

Conditions: Fertility Issues

Treatments: Other: total cumulative gonadotrophin usage

Study type: Observational

Funder types: Other

Identifiers

NCT06179420

UKMPPI/111/8/JEP-2023-735

Details and patient eligibility

About

This prospective study is subject to approval of institutional medical research ethics committee. Patient undergoing second cycle IVF will be enrolled into the intervention group. Intervention involved using a clinical decision support tool, Opt-IVF to guide gonadotrophins dosing and trigger dates for a personalized controlled ovarian stimulation cycle based on the distribution of follicle sizes on day 1 and day 5, and hormone dosages given on day 1 to 4.

Patients will undergo transvaginal ultrasound exam on day 1 and day 5 of the cycle to determine the number and size of follicles present. The data is used in the Opt-IVF decision support tool to suggest Gonadotropin dosage for D5 and beyond and to recommend the antagonist start day and trigger day.

Clinical investigators will not override the Opt-IVF recommended dosage in any patients.

Full description

The total dosage of gonadotrophin, number of good quality oocytes and blastocyst will be analyzed from each arm.

Enrollment: 30 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient undergoing 2nd cycle of IVF

Exclusion criteria

• Polycystic ovarian syndrome patient

Trial design

30 participants in 2 patient groups

standard IVF regime protocol based on clinician decision

Description:

The dosage of gonadotrophin and time of transvaginal ultrasound decided by clinician

Treatment:

Other: total cumulative gonadotrophin usage

clinical decision support tool, Opt-IVF for IVF regime protocol

Description:

The dosage of gonadotrophin and time of transvaginal ultrasound decided by a clinical decision support tool ( OPt -IVF)

Treatment:

Other: total cumulative gonadotrophin usage