the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR)

Guangdong Provincial People's Hospital (Guangdong Provincial Academy of Medical Sciences)

Status: Not yet enrolling

Conditions: Cardiac Arrest (CA); ACLS; Out-of-hospital Cardiac Arrest (OHCA); CPR

Treatments: Procedure: CPR

Study type: Interventional

Funder types: Other

Identifiers

NCT07258823

ChiCTR2400094466

Details and patient eligibility

About

Bio-CPR is an innovative new mechanical resuscitation model proposed by our research group. A multi-center RCT study was established to comprehensively evaluate the efficacy of this model and the current standard CPR protocol, verify its safety and efficacy, and provide high-quality clinical evidence support.

Enrollment: 408 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 18-65 years old; 2. Cardiac arrest with witnesses; 3. Onset - compression start time<5 minutes; 4. Initial ventricular fibrillation rhythm; 5. Endotracheal intubation and use of a mechanical chest CPR device; Patients with OHCA who meet the above conditions

Exclusion criteria

• 1. OHCA patients who are not suitable for mechanical compression ventilation; 2. The participant or his/her legally authorized representative (LAR) is unable or unwilling to provide written informed consent.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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408 participants in 2 patient groups

Bio-CPR experimental group

Experimental group

Description:

Bio-CPR ventilation mode

Treatment:

Procedure: CPR

Traditional compression/ventilation mode group

Active Comparator group

Description:

Traditional compression/ventilation mode

Treatment:

Procedure: CPR