The Effectiveness of Dialectical Behavioral Group Psychotherapy Compared to Supportive Individual Psychotherapy In Patients With Borderline Personality Disorder: A Study on Therapeutic Alliance, Depression, Cognitive Function, Impulsivity, Suicide Risk, BDNF Levels, NFkB Levels, SOD Levels (DBT BPD)

Natalia Dewi Wardani, MD

Status: Completed

Conditions: Borderline Personality Disorder (BPD)

Treatments: Behavioral: Supportive Psychotherapy; Behavioral: DBT group psychotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT07449104

976/EC/KEPK-RSDK/2021

247/UN7.5.4/HK/2022 (Other Grant/Funding Number)

Details and patient eligibility

About

In the context of therapy for Borderline Personality Disorder, our department had conduct a study titled "The Effectiveness of Dialectical Behavioral Group Psychotherapy Compared to Supportive Individual Psychotherapy in Patients with Borderline Personality Disorder: A Study of Therapeutic Alliance, Depression, Cognitive Function, Impulsivity, Suicide Risk, BDNF Levels, NFkB Levels, SOD Levels."

Full description

Psychotherapy for Borderline Personality Disorder provided weekly for 13 weeks. Patients have given a logbooks. Researchers monitored patients weekly by telephone and monitor them during outpatient visits in the second, fourth, sixth, eighth, and twelfth weeks. Blood samples were taken before and 13 weeks after treatment. During the study, patients were advised not to consume any medications or herbal remedies outside of those prescribed by the doctor and recorded in the study.

Enrollment: 66 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18-60 years old
• Diagnosed with Borderline Personality Disorder based on the Structured Clinical Interview for DSM-V Axis II Disorders (SCID-II)
• Junior high school education or higher
• Patients willing to participate in the study.

Exclusion criteria

• Taking immunosuppressive drugs since one week before the study.
• Based on interviews or medical records, there is no history of post-stroke, epilepsy, or diabetes mellitus.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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66 participants in 2 patient groups

DBT group psychotherapy

Experimental group

Description:

13 weeks, one session per week. Each week, 2-hour dialectical therapy group session for 5 patients per group.

Treatment:

Behavioral: DBT group psychotherapy

Suportive psychotherapy

Active Comparator group

Description:

13 weeks, one session per week. Each week, one 30-minute session of individual supportive psychotherapy.

Treatment:

Behavioral: Supportive Psychotherapy