the Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis

South Valley University

Status and phase: Unknown; Phase 4

Conditions: Iron-deficiency

Treatments: Drug: Lactoferrin; Drug: Ferric Hydroxide Polymaltose

Study type: Interventional

Funder types: Other

Identifiers

NCT03748043

171984

Details and patient eligibility

About

the investigators will compare the response to iron deficiency anemia to lactoferrin plus ferrous poly maltose versus ferrous poly maltose in Children With Chronic Tonsillitis

Full description

Iron deficiency is frequently present with chronic inflammatory disease.(1) Iron deficiency anemia results from decreased body's iron content due to blood loss, poor dietary iron intake, malabsorption, or increased iron requirement. Immune activation drives a diversion of iron to storage sites, particularly the mononuclear phagocytes system in liver and spleen leads to poor hemoglobinization and anemia. Iron deficiency and immune activation lead to disturbances of iron homeostasis.(2) this trial will compare the response to iron deficiency anemia to lactoferrin plus ferrous poly maltose versus ferrous poly maltose in Children With Chronic Tonsillitis

Enrollment: 100 estimated patients

Sex: All

Ages: 3 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children 3-17 years old with chronic tonsillitis

Exclusion criteria

• no other causes of Iron Deficiency Anemia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

lactoferrin+ferric hydroxide polymaltose

Experimental group

Description:

lactoferrin 100 mg /day plus ferric hydroxide polymaltose 6 mg /kilogram body wight for 3 months

Treatment:

Drug: Ferric Hydroxide Polymaltose

Drug: Lactoferrin

ferric hydroxide polymaltose

Experimental group

Description:

6 mg /kilogram body wight of ferric hydroxide poly maltose per day for 3 months

Treatment:

Drug: Ferric Hydroxide Polymaltose