The Effectiveness of Oral Acyclovir in the Treatment of Molluscum Contagiosum in Children

Dalia Mahran

Status: Unknown

Conditions: Molluscum Contagiosum

Treatments: Drug: Acyclovir; Drug: KOH 10 %

Study type: Interventional

Funder types: Other

Identifiers

NCT04476186

site of study assiut U H

Details and patient eligibility

About

The investigators will study the effectiveness of acyclovir in the treatment of molluscum contagiosum in assiut university hospital - dermatological out patient clinic the treatment group will receive acyclovir 200 mg 5 times per day the controlled group will receive local KOH solution

Full description

Study population:

Site of the study: The outpatient dermatological clinic in Assiut university hospital.

Participants: children (2 -16) years' old attending dermatological clinic in Assiut university hospital and their parents.

Methodology in details:

1. We will use the social media as " Facebook" to invite patient to visit the clinic and follow up them due to the protective measures of covid 19.
2. Diagnosis of the patient with molluscum contagiosum according to the clinical picture
3. Collecting data including personal and clinical data through interviewing the patient and his or her parents
4. Pictures of the lesions will be taken before and after treatment after patient consent.
5. We will Randomly assigning the patient to either treatment group or controlled group according to simple random table
6. Prescribing the treatment according to the patient group
7. Follow up of the patient after 1 weak and each week according to the response to treatment or presence of complication

Inclusion criteria:

Children (5 -15) years old with Molluscum contagiosum.

Exclusion criteria:

1. Molluscum contagiosum with Inflamed spot
2. Known immune compromised children
3. Molluscum lesion in the eye lid.
4. Children with renal impairment.

Enrollment: 35 estimated patients

Sex: All

Ages: 2 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children (2 -16) years old with Molluscum contagiosum.

Exclusion criteria

• Molluscum contagiosum with Inflamed spot Known immune compromised children Molluscum lesion in the eye lid. Children with renal impairment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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35 participants in 2 patient groups, including a placebo group

treatment group

Active Comparator group

Description:

200 mg of oral acyclovir 5 timed per day for 5 days per week for maximum 1 month

Treatment:

Drug: Acyclovir

controlled group

Placebo Comparator group

Description:

KOH 10 % solution local application with apiece of cotton 2 time per day maximum for 1 month

Treatment:

Drug: KOH 10 %