The Effectiveness of Reconstructive Microsurgery on the Clinical and Functional State of Laryngeal Stenosis

Astana Medical University

Status: Unknown

Conditions: Larynx Disease; Laryngeal Stenosis

Treatments: Other: Laryngoscopy; Radiation: MRI and CT; Diagnostic Test: spirometry; Other: electromyography

Study type: Interventional

Funder types: Other

Identifiers

NCT04734483

dr.turayeva (Registry Identifier)

Aliya_Turayeva

Details and patient eligibility

About

To improve diagnostic methods for patients with laryngeal stenosis for the optimal determination of the technique of surgical treatment.

Full description

The study include patients with laryngeal pathology in the otorhinolaryngology clinic of the 1-city hospital at Nur-Sultan city. All patients cheek up the necessary clinical, functional, diagnostic studies and treatment measures. It is planned to examine and operate on 70 patients with laryngeal pathology.

1. To study the features of the course of stenosis of the larynx under the influence of various factors, as well as traumatic injuries.
2. To develop optimal diagnostic methods for patients with laryngeal stenosis.
3. To assess the effectiveness of endolaryngeal microsurgery in patients with laryngeal stenosis.
4. To develop recommendations for the organization of treatment for stenosis of the larynx with an increase its functional state.

Enrollment: 70 estimated patients

Sex: All

Ages: 1 to 74 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• medically diagnosed with stenosis of larynx
• patients who were observed larynx by MRI and CT
• patients who need surgical treatment of stenosis of larynx

Exclusion criteria

• pregnancy
• patients who has positive electromyography findings of motion of laryngeal muscles
• patients who has contraindications to surgical treatment on the other diseases
• patients who has not normal results of lab. analyses

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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70 participants in 4 patient groups

functional findings

Active Comparator group

Description:

Participants with laryngeal stenosis

Treatment:

Diagnostic Test: spirometry

to find anatomic feathers of larynx

Active Comparator group

Description:

Participants with laryngeal stenosis

Treatment:

Other: Laryngoscopy

Radiation: MRI and CT

to determine the type of stenosis of larynx and method of surgical treatment

Active Comparator group

Description:

Participants with laryngeal stenosis

Treatment:

Diagnostic Test: spirometry

Other: Laryngoscopy

Other: electromyography

Radiation: MRI and CT

determining the motor abilities of the muscles of the larynx

Active Comparator group

Description:

Participants with laryngeal stenosis

Treatment:

Other: electromyography