The Effectiveness of Titanium-Prepared Platelet-Rich Fibrin on Angiogenic Biomarkers in Gingival Crevicular Fluid (T-PRF)

Kırıkkale University

Status: Completed

Conditions: Chronic Periodontitis; Intrabony Periodontal Defect

Treatments: Procedure: Allograft; Procedure: T-PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT02692079

2014/18

Details and patient eligibility

About

This study investigates the effect of titanium-prepared platelet-rich fibrin (T-PRF) treatment on the angiogenic biomarkers in gingival crevicular fluid (GCF) in infrabony defects of patients with chronic periodontitis. In each patient, the infrabony defect of one side of arch was designated as control group (allograft), while the infrabony defect on the contralateral side of same arch was designated as test group (allograft+T-PRF).

Full description

Platelets are the cells initiating the wound healing and also supporting it by secreting various growth factors actively. These growth factors released by platelets act the increase of connective tissue healing, bone regeneration and repair, fibroblast mitogenesis, wound angiogenesis and the activation of macrophages by stimulating cell proliferation signals.

Titanium-prepared, platelet-rich fibrin (T-PRF), is a new platelet concentrate, is formed in titanium tubes may be more efficient to activate platelets in comparison with glass tubes.The titanium tubes is utilized to refrain any inverse effects of glass tubes and also silica.

Enrollment: 25 patients

Sex: All

Ages: 26 to 59 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical Diagnosis of Chronic Periodontitis
• The presence of two or three-wall intrabony defects≥3 mm deep along with an interproximal probing depth ≥5 mm after non-surgical periodontal therapy

Exclusion criteria

• Systemic illnesses
• Any medications known to affect the outcomes of periodontal surgery
• Pregnancy and lactation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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25 participants in 2 patient groups

T-PRF+Allograft

Experimental group

Description:

The defects were debrided and root planed with ultrasonic instrumentation and area-specific curets. All sites were washed with sterile salin solution and bleeding control was performed. Test group sites were treated with T-PRF+allograft

Treatment:

Procedure: Allograft

Procedure: T-PRF

Allograft

Experimental group

Description:

The defects were debrided and root planed with ultrasonic instrumentation and area-specific curets. All sites were washed with sterile salin solution and bleeding control was performed. Control group sites were treated with only allograft

Treatment:

Procedure: Allograft