The Effectiveness of Vancomycin in Comarison With Cefazolin in Prevention of SSI After Craniotomy

Isfahan University of Medical Sciences

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Elective Craniotomy-candidated Patients

Treatments: Drug: Cefazolin; Drug: Vancomycin

Study type: Interventional

Funder types: Other

Identifiers

NCT03466645

Isfahan University

Details and patient eligibility

About

Surgical-site infection is the most commonly reported nosocomial infection in patients undergoing surgery and 3rd most nosocomial infection in hospitalized patients. The SSI is associated with increases of length of hospitalization for 6 days and increases the hospital's cost by $ 300.

Because of these, prevention of SSI with appropriate antibiotic is essential.

Enrollment: 126 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18 years and above
• elective surgical patients
• No pre-surgery infection
• Do not use antibiotics before surgery
• Insensitivity to beta-lactam antibiotics

Exclusion criteria

• cranioplasty
• Failure to follow the patient
• The patient's unwillingness to continue participating in the research project
• Death of the patient

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

126 participants in 2 patient groups

1st group, receiving vancomycin

Active Comparator group

Description:

The 1st group receives vancomycin an hour before craniotomy

Treatment:

Drug: Vancomycin

2nd group, receiving cefazolin

Active Comparator group

Description:

The 2nd group receives cefazolin an hour before craniotomy

Treatment:

Drug: Cefazolin