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The Effectiveness of YAG Iridotomy in Preventing Peripheral Anterior Synechia After CLASS in Primary Open Angle Glaucoma

Zhejiang University logo

Zhejiang University

Status

Unknown

Conditions

Glaucoma, Open-angle

Treatments

Device: YAG iridotomy

Study type

Interventional

Funder types

Other

Identifiers

NCT04912362
2020-527

Details and patient eligibility

About

To investigate the effectiveness of YAG laser iridotomy in preventing peripheral anterior synechia after CO2 Laser-Assisted Sclerectomy Surgery and the long-term effect of reducing intraocular pressure

Full description

Group A: YAG laser iridotomy was performed one week before operation, followed by CO2 Laser-Assisted Sclerectomy Surgery; Group B: only CO2 Laser-Assisted Sclerectomy Surgery; The patients were followed up for 1 year to observe and compare the difference of the incidence of peripheral anterior synechia and the effect of long-term intraocular pressure control between the two groups.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Primary open angle glaucoma patients in Ophthalmic Center;
  • Topical use of hypotensive drugs in the treatment of poor or intolerable intraocular pressure control;
  • The patients were 18 to 50 years old, regardless of gender;
  • Class operation was performed;
  • Patients are able and willing to comply with the research guidance and may complete all visits required by the research;
  • Informed consent has been signed.

Exclusion criteria

  • Allergic to any perioperative medication in this study;
  • History of ocular trauma;
  • Any previous intraocular surgery;
  • Gonioscopy showed a narrow angle (Schaffer III or below);
  • Secondary glaucoma was diagnosed;
  • Optic atrophy caused by other reasons;
  • Severe complications such as rupture of posterior capsule and choroidal hemorrhage occurred during operation;
  • Patients with severe ocular complications after operation
  • The patient's history indicated that he had severe dysfunction of heart, lung, liver and kidney;
  • Women in pregnancy, lactation or planned pregnancy;
  • The researchers believe that the patient's condition may put the patient at significant risk, may confuse the results of the study, or may significantly interfere with the patient's participation in the study.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

80 participants in 2 patient groups

YAG iridotomy+CLASS
Experimental group
Description:
YAG iridotomy was performed one week before operation, and then CO2 Laser-Assisted Sclerectomy Surgery was performed
Treatment:
Device: YAG iridotomy
CLASS
No Intervention group
Description:
CO2 Laser-Assisted Sclerectomy Surgery only

Trial contacts and locations

1

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Central trial contact

Kaijun Wang, MD

Data sourced from clinicaltrials.gov

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