The Effects of Acupuncture on the Natural Pregnancy in Patients With Recurrent Abortion

Jianmei Xia

Status: Completed

Conditions: Ultrasound Therapy; Coagulation; Recurrent Spontaneous Abortion; Acupuncture

Treatments: Drug: routine aspirin and heparin treatment; Procedure: acupuncture

Study type: Interventional

Funder types: Other

Identifiers

NCT05998421

2023003

Details and patient eligibility

About

Recurrent spontaneous abortion (RSA) is a common pregnancy complication in women of reproductive age and the cause of RSA remains largely unclear. Acupuncture is widely used in clinical practice to treat infertility and abortion. The role of acupuncture in the treatment of infertility is still unclear. The investigators conducted a randomized, prospective, controlled clinical trial to investigate its potential impact on pregnancy outcome. Herein, the investigators not only evaluated the changes in patients' psychological stress before and after treatment but also followed up on pregnancy outcomes. In addition, changes in uterine artery blood flow were observed by ultrasound. Changes in coagulation-related indicators were also detected.

Full description

To better illustrate the effectiveness and mechanism of acupuncture in infertility, especially in RSA patients, the investigators conducted a randomized, prospective, controlled clinical trial to investigate its potential impact on pregnancy outcome. Herein, the investigators not only evaluated the changes in patients' psychological stress before and after treatment but also followed up on pregnancy outcomes. In addition, changes in uterine artery blood flow were observed by ultrasound. Changes in coagulation-related indicators were also detected. The investigators hypothesized that acupuncture could promote and improve pregnancy by improving uterine artery blood flow and relieving patients' anxiety symptoms. To our knowledge, it has never been reported before.

Enrollment: 46 patients

Sex: Female

Ages: 25 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• had a previous RSA history;
• had a normal body mass index (BMI) of 18-25 kg/m2;
• had no acute infection of the abdomen and low back skin;
• had no history of liver or kidney disease.

Exclusion criteria

• acute infection in the abdomen or lower back
• planning assisted reproductive technologies (ART) in the next 3 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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46 participants in 2 patient groups

the drug group (control group)

Active Comparator group

Description:

The patients in the control group accepted routine aspirin and heparin treatment. Two months before pregnancy, 50 mg of aspirin (Chenxin Pharmaceutical, China) was taken orally once a day.

Treatment:

Drug: routine aspirin and heparin treatment

the drug-accompanied-by-acupuncture group (acupuncture group)

Experimental group

Description:

The patients in the acupuncture group accepted acupuncture treatment weekly from the second day of menstruation and three times in one cycle.

Treatment:

Procedure: acupuncture

Drug: routine aspirin and heparin treatment