The Effects of Altering Physical Activity on Cardiometabolic Health (PIA)

University of Kansas

Status: Completed

Conditions: Insulin Resistance

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01879059

PIA-1200428

Details and patient eligibility

About

The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular health. Specifically, the investigators wish to examine in healthy, lean physically active individuals (obtaining greater than 10,000 steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter blood flow following a meal a marker of vascular health. Furthermore, the investigators wish to examine if a one day return to physical activity (obtaining >10,000 steps/day) can restore the detrimental effects on blood flow following a meal.

Full description

Herein, we tested the hypothesis that an acute reduction in daily activity (from >10,000 to <5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and if a 1 day return to activity improved this outcomes.

Enrollment: 13 patients

Sex: All

Ages: 19 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI: less than 30 kg/m2
• Physically active: exercise greater than 60mins per week

Exclusion criteria

• smoking
• type 2 diabetes
• Underlying conditions that limit ability to exercise safely
• Recent weight gain or loss(> 5% of body weight in 3 months)
• Recent (< 3 mo) changes in medication use or dose
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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13 participants in 1 patient group

Exercise

Experimental group

Description:

5 days of inactivity followed by a 1 day return to physical activity

Treatment:

Behavioral: Exercise