The Effects of Amino Acid Supplement During Acute Inflammation.
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About
The purpose of the study is to investigate the metabolic effects during acute inflammation with and without the nutritional supplement of amino acids.
E. Coli Endotoxin (LPS, lipopolysaccharide) is used to initiate an inflammatory response.
The study is an interventional randomized placebo study including 8 healthy male subjects. Each subject participates 3 times (different days) and are given one of following interventions:
- Placebo (NaCl)
- Endotoxin, US standard reference E.Coli + Placebo (NaCl)
- Endotoxin, US standard reference E.Coli + Amino acids (intravenously)
It is our hypothesis that the nutritional intervention during acute inflammation plays an important role in lipid and protein metabolism.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- male gender
- 20<BMI<30
- Age > 25 years old
- Written consent before starting the study
Exclusion criteria
- Allergy for soya products ore egg
- Diabetes
- Epilepsy
- Infection
- Immune defects
- Heart disease
- Dysregulated hypertension
- Participating in other trials using radioactive tracers or x-rays the last year.
Trial design
Primary purpose
Allocation
Interventional model
Masking
8 participants in 3 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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