The Effects of Aspartame on Appetite, Body Composition and Oral Glucose Tolerance

Purdue University

Status: Completed

Conditions: Oral Glucose Tolerance

Treatments: Other: aspartame; Other: water

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02999321

055-045

Details and patient eligibility

About

Assess the impact of chronic use of aspartame on glycemia, appetite and body composition.

Full description

Participants will be randomly assigned to one of three parallel arms: 0% (water), 5 mg, 15mg aspartame. Participants will have an oral glucose tolerance test at the beginning and end of a 12 week intervention. . Participants will report to the lab weekly for 12 weeks to pick up their next week's intervention products and measurements for body weight, waist circumference, blood pressure and heart rate. They will consume their intervention products daily for 12 weeks. They will record appetite sensations and collect a 24 hour urine sample at weeks 0, 4, 8, and 12.

Enrollment: 93 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 18-25
• Fasting blood sugar between 72 and 108 mg/dl via capillary finger-stick.

Exclusion criteria

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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93 participants in 3 patient groups

0% aspartame (water)

Experimental group

Description:

participants will not have any aspartame, this is a control.

Treatment:

Other: water

5 mg aspartame

Experimental group

Description:

participants will receive 5 mg aspartame in a beverage.

Treatment:

Other: aspartame

15mg aspartame

Experimental group

Description:

participants will receive 5 mg aspartame in a beverage, and 10mg in capsules.

Treatment:

Other: aspartame