The Effects of AZT and Ibuprofen on HIV-Infected Patients With Hemophilia

University of Pittsburgh

Status: Completed

Conditions: Hemophilia A; HIV Infections

Treatments: Drug: Zidovudine; Drug: Ibuprofen

Study type: Interventional

Funder types: Other

Identifiers

NCT00002276

044A

Details and patient eligibility

About

To determine if platelet dysfunction and/or pharmacologic drug interaction occurs in patients taking both AZT and ibuprofen, which might account for enhanced bleeding tendency.

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Patients must have:

• Hemophilia.
• HIV-seropositivity confirmed by Western Blot.

Prior Medication:

Required:

• AZT for study patients.

Allowed:

• Ibuprofen.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms and conditions are excluded:

Hospitalization for opportunistic infection, bacterial infection or malignancy.

Concurrent Medication:

Excluded:

• AZT (for control group).
• Antibiotics or other medication for opportunistic infection, bacterial infection, or malignancy.

Patients with the following prior conditions are excluded:

Hospitalization for opportunistic infection, bacterial infection, or malignancy.

Required:

• Ibuprofen.
• AZT 1-2 gm daily (for study patient) or not taking AZT (for control).