The Effects of β-Hydroxy-β-methylbutyrate Free Acid and High-Intensity Interval Training

Metabolic Technologies

Status: Completed

Conditions: Exercise

Treatments: Dietary Supplement: Placebo; Dietary Supplement: HMB-FA; Procedure: High Intensity Interval Training

Study type: Interventional

Funder types: Industry

Identifiers

NCT01941368

13-257 (Other Identifier)

MTI2013-CS03

Details and patient eligibility

About

Objectives: 1) Determine the effect of 4-weeks of high intensity interval training (HIIT) and free acid form β-Hydroxy-β-methylbutyrate (HMB-FA) on VO2peak, lactate threshold, critical power, anaerobic working capacity and neuromuscular economy in a population of endurance trained individuals. 2) Determine the effect of 4-weeks of HIIT and HMB-FA on changes in skeletal muscle physiological cross-sectional area (PCSA=Volume/Fascicle length) and muscle quality (MQ=echo intensity) in the rectus femoris and vastus lateralis.

Subjects: Fifty males and females between the ages of 18 - 35 will be recruited to participate in this study. Subject will be randomized to one of three groups: a control group (CTL), an HIIT only group (HIIT) or a group which will take the amino acid metabolite HMB and perform HIIT (HMB-HIIT). Individuals assigned to CTL will undergo baseline testing. They will then be asked to continue their normal exercise routine for 4 weeks and will undergo post-testing after this time period.

Study Protocol: Two testing sessions, on nonconsecutive days, will occur at least 72 hours prior to the start of the training period. The same testing protocols will be repeated at the end of the 4-week training period. Testing protocols include performance testing (VO2peak, lactate threshold, critical power, anaerobic working capacity and neuromuscular economy) and anthropometric measures (physiological cross-sectional area and muscle quality). The training protocol for individuals in the experimental groups will consist of 4-weeks of high intensity interval training with three sessions per week on an electronically braked cycle ergometer. Individual work -loads will be calculated based on the outcomes from each participant's preliminary testing.

Enrollment: 40 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Recreationally-trained individuals with a VO2peak>40 ml∙kg-1∙min-1.
• Free of any physical limitations as determined by the Confidential Medical and Activity questionnaire and/or PAR-Q
• Between the ages of 18 and 35

Exclusion criteria

• Inability to perform physical exercise, as determined by the Confidential Medical and Activity questionnaire and/or PAR-Q
• Any chronic illness that causes continuous medical care

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 3 patient groups, including a placebo group

Control

No Intervention group

Description:

Individuals assigned to Control Group will undergo baseline testing and then be asked to continue their normal exercise routine for 4 weeks and will undergo post-testing (visits 16 and 17) after this time period.

Placebo + High-Intesnity Interval Training (HIIT)

Placebo Comparator group

Description:

On training days, individuals will consume 1 gram of placebo 30 min prior to training, 1gram placebo 1 hour post training, and 1gram placebo 3 hours post training. On non-training days, individuals will consume placebo 3 times per day (8am, 12pm and 4pm).

Treatment:

Dietary Supplement: Placebo

Procedure: High Intensity Interval Training

HMB-FA + HIIT

Active Comparator group

Description:

On training days, individuals will consume 1 gram HMB-FA 30 min prior to training, 1gram HMB-FA 1 hour post training, and 1gram HMB-FA 3 hours post training. On non-training days, individuals will consume HMB-FA 3 times per day (8am, 12pm and 4pm).

Treatment:

Procedure: High Intensity Interval Training

Dietary Supplement: HMB-FA