The Effects of Blood Pressure Reduction on Cerebral Perfusion and Cognition in the Elderly Population (MBRACE)

Radboud University Medical Center

Status and phase: Unknown; Phase 4

Conditions: Hypertension

Treatments: Drug: anti-hypertensive medication

Study type: Interventional

Funder types: Other

Identifiers

NCT00966199

2008B113

MBRACE

Details and patient eligibility

About

The purpose of this study is to determine if a reduction in systolic blood pressure induced by anti-hypertensive medication results in changes in cerebral perfusion and cognition in hypertensive elderly. Hypertensive elderly will be treated using open-label anti-hypertensive medication for 8-12 weeks. Changes in cerebral perfusion and cognition will be assessed before and after treatment.

Enrollment: 60 estimated patients

Sex: All

Ages: 70+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >= 70 years
• Systolic office blood pressure >= 160 mmHg
• Systolic home blood pressure >= 155 mmHg

Exclusion criteria

• Diabetes Mellitus
• Atrial fibrillation
• Dementia
• Renal failure requiring dialysis
• Life expectancy of less than 1 year
• Disabling stroke
• Contraindication for MRI or anti-hypertensive medication
• Systolic blood pressure > 220 mmHg

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

Hypertensive elderly

Experimental group

Description:

community dwelling hypertensive elderly from general practices

Treatment:

Drug: anti-hypertensive medication