The Effects of Bolus, Intermittent and Continuous Enteral Feeding on Blood Glucose and Feeding Intolerance in ICU Patients With Sepsis

Umraniye Education and Research Hospital

Status: Not yet enrolling

Conditions: Enteral Feeding Intolerance

Treatments: Procedure: blood glucose measurements; Other: enteral feeding; Procedure: Evaluation of feeding intolerance with gastric residue

Study type: Interventional

Funder types: Other

Identifiers

NCT05812664

ENTERAL FEEDİNG

Details and patient eligibility

About

Comparison of the effects of bolus, intermittent and continuous enteral feeding techniques on plasma glucose level and enteral feeding intolerance in adult intensive care unit patients with sepsis.

Full description

in this prospective, controlled trial the main aim is to evaluate the effects of bolus, intermittent and continuous enteral feeding techniques on plasma glucose level in intensive care patients with sepsis diagnosis and to determine whether they are superior to each other in providing norma-glycemia. The secondary aim is to determine the effect of these 3 different enteral feeding techniques on enteral feeding intolerance.

Enrollment: 93 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalized in ICU for more than 3 days
• Ages between 18-70 years
• APACHI II is in the range of 8-25
• BMI in the range of 18.5-30
• Able to receive enteral nutrition from N/G
• Intubated on ventilator support
• No previous diagnosis of Diabetes Mellitus,
• Those who have not had Gastro intestinal System surgery in the last 6 months
• Patients not receiving inotropic support
• not receiving hemodiafiltration
• No history of allergy to the food used
• Patients with a focus of infection and/or culture-positive patients diagnosed with sepsis according to Q SOFA (cultures were taken from all patients)

Exclusion criteria

• patient's death during the study
• Taking more than 40 mg of IV steroids daily
• Increased baseline APACHI II score
• Development of the patient's need for inotropes
• Elimination of inclusion criteria
• negative culture

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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93 participants in 3 patient groups

bolus feeding group

Experimental group

Description:

bolus feeding method;The amount of food to be given for 24 hours calculated for the patient was given as 4 equal amounts for 40 minutes at 4 different times. Starting with 150 cc, the target calorie was reached by increasing 100 cc according to the intolerance before the next feeding hour.

Treatment:

Procedure: blood glucose measurements

Procedure: Evaluation of feeding intolerance with gastric residue

Other: enteral feeding

intermittent feeding group

Experimental group

Description:

The formula was started as 40 cc/h continuous infusion. It was interrupted after 5 hours. 30 minutes after the break, PGD was measured and intolerance was checked, and if the residue was negative, it was increased by 40 cc. The amount was increased until reaching the amount of formula that should be given for 24 hours calculated for the patient. This cycle was repeated 3 times in 24 hours. At 24:00, it was stopped and feeding was interrupted between 24:00 and 06:00.

Treatment:

Procedure: blood glucose measurements

Procedure: Evaluation of feeding intolerance with gastric residue

Other: enteral feeding

continous feeding group

Active Comparator group

Description:

The same method was applied as in Group 2. However, after 24:00, feeding was not interrupted and continued as the 4th cycle.

Treatment:

Procedure: blood glucose measurements

Procedure: Evaluation of feeding intolerance with gastric residue

Other: enteral feeding