The Effects of C-type Natriuretic Peptide on Human Forearm Blood Vessels

Queen Mary University of London

Status: Withdrawn

Conditions: Ischaemia-reperfusion (IR) Injury

Treatments: Drug: Acetylcholine; Drug: Saline; Drug: C-type natriuretic peptide (CNP)

Study type: Interventional

Funder types: Other

Identifiers

NCT01075776

007143

Details and patient eligibility

About

To determine the effects of whether increasing CNP concentrations slightly above normal will improve the functioning of blood vessels after the interruption in the flow of blood. In this study we are looking at the function of the blood vessels of the forearm, as a substitute for those in the heart

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy human volunteers on no systemic medication, excepting the oral contraceptive pill

Exclusion criteria

• History of medical illness
• Unwillingness to sign consent form
• Use of non-OCP medications
• Hypertension on examination of the blood pressure

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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0 participants in 2 patient groups, including a placebo group

CNP

Experimental group

Description:

Infusion of CNP prior to IR injury

Treatment:

Drug: Acetylcholine

Drug: C-type natriuretic peptide (CNP)

Saline

Placebo Comparator group

Description:

Effect of saline infusion prior to IR injury

Treatment:

Drug: Acetylcholine

Drug: Saline