The Effects of Caffeinated Coffee on Intraocular Pressure

Mass Eye and Ear

Status: Completed

Conditions: Primary Open Angle Glaucoma

Treatments: Other: Caffeinated Coffee; Other: Decaffeinated Coffee

Study type: Interventional

Funder types: Other

Identifiers

NCT01364207

09-06-052

Details and patient eligibility

About

High intraocular pressure (IOP) is a known risk factor for developing primary open-angle glaucoma (POAG). There is controversy in the literature regarding the degree to which caffeine influences IOP, with some studies reporting minimal changes in IOP while others report up to 4 mmHg increases. To date there are no double-masked randomized controlled trials that examine acute caffeinated coffee's effects on IOP in patients with or at risk for primary open-angle glaucoma. The investigators aim to better understand the relationship between acute caffeinated coffee (vs decaffeinate coffee) consumption and IOP in a double-masked, crossover randomized controlled clinical trial.

Enrollment: 112 patients

Sex: All

Ages: 40 to 89 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 40-89 yrs
• POAG for cases or no forms of glaucoma for controls
• Willingness to drink coffee
• Consent signed

Exclusion criteria

• Age less than 40 or greater than 89 yrs
• all forms of glaucoma other than POAG
• any condition inappropriate for tonometry (ie corneal disease, LASIK)
• unable or unwilling to give consent
• unable or unwilling to drink coffee
• pregnancy

Trial design

112 participants in 2 patient groups

Caffeinated Coffee 1st Visit, Decaffeinated Coffee 2nd Visit

Experimental group

Description:

Participants will be given an 8 oz cup of caffeinated coffee on their first visit and 8 oz cup of decaffeinated coffee on their second visit.

Treatment:

Other: Caffeinated Coffee

Other: Decaffeinated Coffee

Decaffeinated Coffee 1st Visit, Caffeinated Coffee 2nd Visit

Experimental group

Description:

Participants will be given an 8 oz cup of decaffeinated coffee on their first visit and 8 oz cup of caffeinated coffee on their second visit.

Treatment:

Other: Caffeinated Coffee

Other: Decaffeinated Coffee