The Effects of Celecoxib on Bone Ingrowth

Utah System of Higher Education (USHE)

Status and phase: Terminated; Early Phase 1

Conditions: Bone Ingrowth; Pain

Treatments: Drug: Celecoxib

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00585156

IIR#2005-0300

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of Celebrex on bone growth into porous coated implants, following postoperative total knee arthroplasty administration of Celebrex for pain relief.

Enrollment: 9 patients

Sex: Male

Ages: 18 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male VA bilateral TKA patients 18 years or older with primary OA diagnosis

Exclusion criteria

• Patients with osteoporosis, hypersensitivity to Celebrex, allergy to tetracycline, Sulfonamides, patient with asthma, urticaria, or allergic-type reactions to aspirin or NSAIDs.
• Patients who have had CABG.
• Patients with a history of peptic ulcer disease, duodenal ulcers.
• Female patients and patients diagnosed with unstable hypertension or hypotensive, with serum creative levels above 1.8-2.0 or diagnosed with severe renal disease.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

---

9 participants in 1 patient group

Arm #1

Experimental group

Description:

Celebrex treatment group

Treatment:

Drug: Celecoxib