the Effects of Cerebral Collateral Circulation on the Outcome of Leukoaraiosis in High-risk Population

Fudan University

Status: Unknown

Conditions: Leukoaraiosis

Study type: Observational

Funder types: Other

Identifiers

NCT03246373

CSA2016KY001

Details and patient eligibility

About

This study observed the relationship between cerebral collateral circulation and the prognosis of leukoaraiosis in high-risk population. Cerebral collateral circulation and leukoaraiosis levels will be evaluated and followed up by magnetic resonance examination. The participants' clinical performance caused by leukoaraiosis will be assessed by a series of scales.

Full description

1. Case collection information is sent daily to clinical trial supervisors.

2. The clinical trial team meets once a week to monitor the quality of clinical trials.

3. The severity of the leukoaraiosis will be evaluated by a scale. The patients whose score is more than 2 will take additional magnetic resonance examination including magnetic resonance angiography (MRA) and arterial spin labeling (ASL). And their cognitive ability will be evaluated by a series of scales including Mini-Mental State Examination (MMSE) and Montreal cognitive assessment (MoCA) and gait by the short physical performance battery (SPPB).

   The blood sample will be taken for biochemical detection and hair and nail samples for trace element detection.

4. Data were analyzed by regression analysis.

Enrollment: 1,037 estimated patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Physical Examinees or out-patients
• The MRI scale score ≥ 2

Exclusion criteria

• History of stroke
• History of malignant tumor
• History of connective tissue disease
• Pregnant, trying to become pregnant or within 6 weeks after delivery
• serious infections