The Effects of Continuous Positive Airway Pressure (CPAP) on Sympathetic Activity in Different Sites of Activation

University of Sao Paulo

Status and phase: Unknown; Phase 3

Conditions: Catecholamines; Blood Pressure Monitoring, Ambulatory; Sympathetic Nerve Activity; Exercise Test; Radionuclide Imaging (MIBG Scintigraphy)

Treatments: Device: CPAP

Study type: Interventional

Funder types: Other

Identifiers

NCT01336335

Sympathetic activity and OSA

Details and patient eligibility

About

Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension. However, there are few data regarding the impact of OSA on the sympathetic system in apparently normotensive patients with OSA as well as the impact of treatment with continuous positive airway pressure in different sites of activation (heart, peripheral nerves and circulating catecholamines)

Enrollment: 20 estimated patients

Sex: Male

Ages: 30 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Severe OSA males

Exclusion criteria

• Smoking

  • Sustained Hypertension
  • Heart failure
  • Diabetes
  • Renal diseases
  • Under use of any medication
  • Under treatment for OSA

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

CPAP

Experimental group

Description:

OSA treatment with CPAP

Treatment:

Device: CPAP

control

No Intervention group

Description:

no intervention