The Effects of COX-inhibiting Drugs on Skeletal Muscle Adaptations to Resistance Exercise in Healthy Adults (NSAID2015)

Karolinska Institute

Status and phase: Completed; Phase 2

Conditions: Skeletal Muscle Mass Regulation

Treatments: Drug: Acetylsalicylic acid; Drug: Ibuprofen

Study type: Interventional

Funder types: Other

Identifiers

NCT02531451

2014-004872-47

Details and patient eligibility

About

In this study, healthy human subjects (18-35 yrs) are be randomised to consume 1200 mg ibuprofen or 75 mg acetylsalicylic acid daily during a training period of 8 weeks. During these weeks, subjects perform 2-3 supervised strength training sessions (knee extensions). Before and after training, muscle volume is measured by MRI, and muscle strength is assessed by isokinetic and isoinertial ergometers. Muscle biopsies are obtained from m. vastus lateralis to study gene and protein expression of markers regulating muscle protein turnover and prostaglandin synthesis.

Enrollment: 34 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Considered healthy
• Moderately trained
• 18-35 yrs

Exclusion criteria

• Cardiovascular disease
• Impaired kidney or liver function
• Lower limb injury
• Pregnancy
• Ulcer or gastrointestinal upsets
• Previous reactions to use of NSAID

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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34 participants in 2 patient groups

Ibuprofen

Experimental group

Description:

Resistance exercise 20 sessions during 8 weeks Daily consumption of 1200 mg ibuprofen (400 mg x 3) during 8 weeks

Treatment:

Drug: Ibuprofen

Acetylsalicylic acid

Active Comparator group

Description:

Resistance exercise 20 sessions during 8 weeks Daily consumption of 75 mg acetylsalicylic acid (75 mg x 1) during 8 weeks

Treatment:

Drug: Acetylsalicylic acid