The Effects of Crocin Supplementation on Metabolic Parameters, Oxidative Stress, AMP- Activated Protein Kinase and Inflammation-promoting Genes Expression in Peripheral Blood Mononuclear Cells in Patients With Type 2 Diabetes

National Nutrition and Food Technology Institute

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Dietary Supplement: placebo; Dietary Supplement: crocin

Study type: Interventional

Funder types: Other

Identifiers

NCT04163757

899

Details and patient eligibility

About

To study the effects of crocin supplement in patients with type 2 diabetes, 50 patients will be randomly allocated to placebo group and 2 tablets of crocin for 12 weeks. At the first and the end of the intervention, lipid profiles, blood pressure, blood sugar, inflammatory and anthropometric factors will be assessed and compared between groups.

Enrollment: 50 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Age of 40 to 65 years type 2 diabetes: and body mass index range of 18.5 to 30 kg/m2

Exclusion criteria

pregnancy or lactation A history of Cardiovascular disease, Pulmonary disease, Renal disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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50 participants in 2 patient groups, including a placebo group

placebo

Placebo Comparator group

Treatment:

Dietary Supplement: placebo

crocin

Active Comparator group

Treatment:

Dietary Supplement: crocin