The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation

NeuroTherapia, Inc.

Status: Completed

Conditions: Intracranial Neurosurgery

Treatments: Drug: propofol; Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT01200433

10-715

Details and patient eligibility

About

The investigators will evaluate the effects of dexmedetomidine and propofol on cerebral blood flow and brain oxygenation during Deep Brain Stimulation (DBS) surgery. Specifically, the investigators will test the hypothesis that dexmedetomidine is non-inferior to propofol for cerebral blood flow as measured by transcranial Doppler and brain oxygenation as measured by near-infrared spectroscopy.

Enrollment: 44 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-III.
• Scheduled for DBS.

Exclusion criteria

• History of dystonia.
• Severe heart failure with ejection fraction less than 30%.
• History of obstructive sleep apnea.
• History of renal failure with creatinine level > 2 mg/dl.
• Allergies to α-2 agonists and propofol.
• Current use of α-2 agonist medications such as clonidine.

Trial design

44 participants in 2 patient groups

propofol

Active Comparator group

Description:

Subjects will be sedated with propofol.

Treatment:

Drug: propofol

dexmedetomidine

Active Comparator group

Description:

Subjects will be sedated with dexmedetomidine.

Treatment:

Drug: dexmedetomidine