The Effects of Dexmedetomidine and Tracheal Intubation on Heart Rate Variability and QTc Interval

Yonsei University

Status: Completed

Conditions: Anesthesia, General

Treatments: Drug: 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min

Study type: Interventional

Funder types: Other

Identifiers

NCT01584570

4-2011-0791

Details and patient eligibility

About

The purpose of this study is to investigate effect of dexmedetomidine and tracheal intubation on heart rate variability and QTc interval.

Enrollment: 80 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient who are regarded as ASA class I
• age 20 to 60
• patient scheduled for Intubation for surgery

Exclusion criteria

• QTc interval > 440 ms
• arrythmia
• Patient who is taking a medicine which effects QTc interval
• HTN
• DM
• renal disease
• hepatic disease
• pregnant
• illiterate

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 3 patient groups

Control

Active Comparator group

Description:

fentanyl 1 mcg/kg before induction

Treatment:

Drug: 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min

D 0.5 group

Experimental group

Description:

Dexmedetomidine 0.5 ug/kg + Propofol + Sevoflurane+ Vecuronium

Treatment:

Drug: 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min

D 1.0 group

Experimental group

Description:

Dexmedetomidine 1.0 ug/kg + Propofol + Sevoflurane+ Vecuronium

Treatment:

Drug: 0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min