The Effects of Dexmedetomidine Dose on Motor Evoked Potentials

Hospital for Special Surgery (HSS)

Status and phase: Terminated; Phase 4

Conditions: Spinal Fusion

Treatments: Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT03378973

2017-1304

Details and patient eligibility

About

This a parallel group, two-arm, randomized superiority trial that will compare the effect of two different doses of dexmedetomidine on motor evoked potentials during spine surgery

Full description

This a parallel group, two-arm, randomized superiority trial that will compare the effect of two different doses of dexmedetomidine on suitability of motor evoked potentials for intraoperative monitoring during spine surgery

Enrollment: 7 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing multi-level posterior spine fusions requiring motor evoked potential monitoring

Exclusion criteria

• Allergy to dexmedetomidine, propofol
• Conditions knows to make recording of motor evoked potentials difficult, including poorly controlled diabetes, severe peripheral neuropathy, severe myelopathy, or previous surgery during which motor evoked potentials were difficult to obtain
• Hepatic disease

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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7 participants in 2 patient groups

High dose dexmedetomidine

Experimental group

Description:

Patients will receive dexmedetomidine 0.5 mcg/kg/hr plus propofol 50 mcg/kg/min

Treatment:

Drug: Dexmedetomidine

Low dose dexmedetomidine

Active Comparator group

Description:

Patients will receive dexmedetomidine 1.0 mcg/kg/hr plus propofol 25 mcg/kg/min

Treatment:

Drug: Dexmedetomidine